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The Leg press machine is a good approximation for squats. It's not a perfect substitute, but it'll do. [ID: leg_press_mach]
First time: Do 10 reps, starting at a low weight
Important: Don't risk knee injury on this machine:
Activate (scrunch) your glutes prior to any lifting on the Leg press machine. "Tell" your body to use your glutes in this exercise. This is a learned behavior that takes some practice. Once you've got it down though, you'll avoid strain on your knees. And bonus: you'll be able to lift a lot more weight.
Progressions: More weight, reps, and sets.
Helpful hint: The debate rages on: machines vs free weights, hints.htm#machines_vs_free_weights
Image source: NASM, nasm.org